120394-66-3

120394-66-3 structure

120394-66-3 structure

Name: HO-PEG6-CH2COOH
Chemical Name: HO-PEG6-CH2COOH
CAS Number: 120394-66-3
Molecular Formula: C₁₄H₂₈O₉
Molecular Weight: 340.37
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 23:28:50
Modify Date: 2024-01-15 11:27:05
HO-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	HO-PEG6-CH2COOH

Description	HO-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₄H₂₈O₉
Molecular Weight	340.37