897771-47-0
897771-47-0 structure
- Name: DC-5163
- Chemical Name: DC-5163
- CAS Number: 897771-47-0
- Molecular Formula: C18H20ClN3OS
- Molecular Weight: 361.89
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-06-01 10:08:37
- Modify Date: 2024-01-05 20:20:02
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DC-5163 is a potent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with an IC50 of 176.3 nM and a Kd of 3.192 μM. DC-5163 can inhibit glycolysis pathway partially. DC-5163 also selectively inhibits cancer cell proliferation and induces apoptosis[1].
| Name | DC-5163 |
|---|
| Description | DC-5163 is a potent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with an IC50 of 176.3 nM and a Kd of 3.192 μM. DC-5163 can inhibit glycolysis pathway partially. DC-5163 also selectively inhibits cancer cell proliferation and induces apoptosis[1]. |
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| Related Catalog | |
| Target |
IC50: 176.3 nM (Glyceraldehyde-3-phosphate dehydrogenase (GAPDH))[1] Kd: 3.192 μM (GAPDH)[1] |
| In Vitro | DC-5163 (100 μM; 48 hours; MDA-MB-231 cells) treatment clearly induces the apoptosis of MDA-MB-231 cells. DC-5163 also significantly reduces glucose uptake, lactate production, and 18F-FDG uptake rate compared to controls in MDA-MB-231cells[1]. DC-5163 treatment at 25 μM inhibits GAPDH activity in BT-549 cells, MCF7 cells, HCT116 cells, MDA-MB-231 cells and A549 cells after 48 hours[1]. DC-5163 inhibits MDA-MB-231 cell proliferation with an IC50 of 99.22 μM at 48 hours and 52.09 μM at 72 hours[1]. Apoptosis Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 100 μM Incubation Time: 48 hours Result: Clearly induced the apoptosis of MDA-MB-231 cells. |
| References |
| Molecular Formula | C18H20ClN3OS |
|---|---|
| Molecular Weight | 361.89 |