866269-28-5
866269-28-5 structure
- Name: AZD8848
- Chemical Name: AZD8848
- CAS Number: 866269-28-5
- Molecular Formula: C29H43N7O5
- Molecular Weight: 569.70
- Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
- Create Date: 2020-06-02 00:28:52
- Modify Date: 2024-02-29 19:46:31
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AZD8848 is a selective toll-like receptor 7 (TLR7) antedrug agonist which is developed for the research of asthma and allergic rhinitis[1].
| Name | AZD8848 |
|---|
| Description | AZD8848 is a selective toll-like receptor 7 (TLR7) antedrug agonist which is developed for the research of asthma and allergic rhinitis[1]. |
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| Related Catalog | |
| Target |
TLR7[1] |
| In Vitro | AZD8848 shows good activity against TLR7, with cellular pEC50s of 7.0 and 6.6 for human TLR7 and rat TLR7, respectively[1]. AZD8848 has an EC50 of 4 nM in the induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for the inhibition of IL-5, irrespective of whether the T cells have been polyclonally stimulated with PHA or via antigen presentation[1]. AZD8848 is a potent, selective TLR7 agonist antedrug able to inhibit Th2 responses in vitro[1]. AZD8848 has no activity against human TLR8 or against any of the other human TLRs[1]. |
| In Vivo | AZD8848 (0.1-1 mg/kg; intratracheal) has a good pharmacokinetics in the Brown Norway rat[1]. AZD8848 (0.3 mg/kg; Intratracheal) suppresses the ovalbumin (OVA) challenge in the rat allergy model[1]. Animal Model: Brown Norway rat allergy model[1] Dosage: 0.1 mg/kg, 1 mg/kg Administration: Intratracheal (24 hours prior to and 24 hours after the OVA challenge) Result: Suppressed OVA challenge in a dose-dependent manner. Animal Model: Brown Norway rat[1] Dosage: 0.3 mg/kg (Pharmacokinetic Analysis) Administration: Intratracheal Result: Has a very short half-life (0.2 min) in rat blood and declined slowly after this point and levels above 1000 nmol/kg were maintained for over 5 hours. |
| References |
| Molecular Formula | C29H43N7O5 |
|---|---|
| Molecular Weight | 569.70 |