2247953-39-3
2247953-39-3 structure
- Name: AHR antagonist 5
- Chemical Name: AHR antagonist 5
- CAS Number: 2247953-39-3
- Molecular Formula: C25H27Cl3FN7
- Molecular Weight: 550.89
- Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
- Create Date: 2020-06-01 19:27:44
- Modify Date: 2025-09-01 18:28:37
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AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1[1].
| Name | AHR antagonist 5 |
|---|
| Description | AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1[1]. |
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| Related Catalog | |
| In Vivo | Tumor growth inhibition is statistically significant with AHR antagonist 5 as single. AHR antagonist 5 (10 mg/kg; p.o.; every day for 3 weeks) combination with anti-PD-1 significantly inhibited tumor growth inhibition compared to the anti-PD-1 alone[1]. Animal Model: Balb/c Mice (Mouse Colorectal Cancer Model CT26)[1] Dosage: 10 mg/kg (combination with anti-PD-1) Administration: P.o.; every day for 3 weeks Result: Significantly inhibited tumor growth inhibition. |
| References |
[1]. Alfredo C. Castro, et al. Indole ahr inhibitors and uses thereof. WO2018195397A2. |
| Molecular Formula | C25H27Cl3FN7 |
|---|---|
| Molecular Weight | 550.89 |