2377151-10-3
2377151-10-3 structure
- Name: ZL0580
- Chemical Name: ZL0580
- CAS Number: 2377151-10-3
- Molecular Formula: C25H23F3N4O4S
- Molecular Weight: 532.53
- Catalog: Signaling Pathways Anti-infection HIV
- Create Date: 2020-04-07 15:32:58
- Modify Date: 2024-01-10 20:29:35
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ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter[1][2][3].
| Name | ZL0580 |
|---|
| Description | ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter[1][2][3]. |
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| Related Catalog | |
| Target |
BRD4 (BD1) |
| In Vitro | ZL0580 (8 μM, 2 days, PBMCs of viremic HIV-infected individuals) induces HIV transcriptional suppression with low toxicity[1]. ZL0580 treatment (10 μM) suppresses both PMA-stimulated and basal HIV transcription[1]. Cell Viability Assay[1] Cell Line: HIV-infected human CD4+ T cells. Concentration: 0-8 μM. Incubation Time: 2 days. Result: Suppress HIV in primary CD4+ T cell. Single treatment (8 μM) led to almost completed loss of productive HIV infection in CD4+ T cells. RT-PCR[1] Cell Line: PBMCs of viremic HIV-infected individuals. Concentration: 8 μM. Incubation Time: 2 days. Result: Suppresses HIV transcription ex vivo in PBMCs of viremic HIV-infected individuals. Cell Cytotoxicity Assay[1] Cell Line: J-Lat cells. Concentration: 0-80 μM. Incubation Time: 1 and 3 days. Result: Did not cause significant cell death at concentrations below 40 μM. Treatment of J-Lat cells with ZL0580 (10 μM) also did not cause significant cell death on days 2, 7, and 14 compared with NC in both PMA-activated and unstimulated cells. |
| References |
| Molecular Formula | C25H23F3N4O4S |
|---|---|
| Molecular Weight | 532.53 |