1515888-53-5
1515888-53-5 structure
- Name: UCB-9260
- Chemical Name: UCB-9260
- CAS Number: 1515888-53-5
- Molecular Formula: C26H25N5O
- Molecular Weight: 423.51
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2020-04-14 18:06:57
- Modify Date: 2024-01-02 20:40:21
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UCB-9260, an orally active compound, inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM[1].
| Name | UCB-9260 |
|---|
| Description | UCB-9260, an orally active compound, inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM[1]. |
|---|---|
| Related Catalog | |
| In Vitro | UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells[1]. UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively[1]. |
| In Vivo | UCB-9260 (150 mg/kg; p.o.;twice daily for 7 days) shows a significant reduction of the clinical score[1]. UCB-9260 (10-300 mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment in adult male Balb/c mice[1]. Animal Model: Aged 6-8 weeks adult male Balb/c mice ( CAIA model)[1] Dosage: 150 mg/kg Administration: p.o.; twice daily for 7days Result: Showed a significant reduction of the clinical score. |
| References |
| Molecular Formula | C26H25N5O |
|---|---|
| Molecular Weight | 423.51 |