2380013-17-0

2380013-17-0 structure

Name: Nampt-IN-5
Chemical Name: Nampt-IN-5
CAS Number: 2380013-17-0
Molecular Formula: C₂₅H₂₅N₅O₂
Molecular Weight: 427.50
Catalog: Signaling Pathways Metabolic Enzyme/Protease Nampt
Create Date: 2020-04-08 15:28:51
Modify Date: 2024-01-20 19:24:47
Nampt-IN-5 is a potent and orally active nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively[1].

Name	Nampt-IN-5

Description	Nampt-IN-5 is a potent and orally active nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt
Target	IC50: Nampt[1]
In Vitro	Nampt-IN-5 (0-10 nM; 3 days) has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively in CellTiterGlo (CTG) assays[1]. Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min*mg), CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6[1].
References	[1]. Palacios DS, et al. Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).ACS Med Chem Lett. 2019 Oct 10;10(11):1524-1529.