1918142-34-3
1918142-34-3 structure
- Name: CFTR corrector 4
- Chemical Name: CFTR corrector 4
- CAS Number: 1918142-34-3
- Molecular Formula: C29H27F2NO7
- Molecular Weight: 539.52
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel CFTR
- Create Date: 2020-04-04 15:51:35
- Modify Date: 2024-01-12 10:18:40
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CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis[1].
| Name | CFTR corrector 4 |
|---|
| Description | CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis[1]. |
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| Related Catalog | |
| Target |
EC50:130 nM (CFTR)[1] |
| In Vitro | CFTR corrector 4 possesses high potency and efficacy with a EC50 of 0.028 μM in this HBE-TECC assay that assess the CFTR function, this lead resides in undesirable drug-like space with high molecular weight, and high HPLC Log D, indicating high lipophilicity. HBE-TECC: (Human Bronchial Epithelial-Trans-Epithelial Current Clamp) assay[1]. CFTR corrector 4 is tested its potency and efficacy in human bronchial epithelial (HBE) cells with a EC50 value 130 nM in the cell surface expression (CSE-HRP) assay[1]. |
| References |
| Molecular Formula | C29H27F2NO7 |
|---|---|
| Molecular Weight | 539.52 |