681514-83-0
681514-83-0 structure
- Name: CCR7 Ligand 1
- Chemical Name: CCR7 Ligand 1
- CAS Number: 681514-83-0
- Molecular Formula: C22H29N5O5S
- Molecular Weight: 475.56
- Catalog: Signaling Pathways GPCR/G Protein CCR
- Create Date: 2020-04-09 19:57:40
- Modify Date: 2024-01-12 15:41:21
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CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM[1].
| Name | CCR7 Ligand 1 |
|---|
| Description | CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM[1]. |
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| Related Catalog | |
| Target |
Human CCR7:3 nM (Kd) Cereblon |
| In Vitro | CCR7 Ligand 1 (CCR7-Cmp2105) binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8[1]. CCR7 Ligand 1 allosterically inhibits binding of the native chemokine CCL19 ligand in scintillation proximity assays (bottom) with an IC50 of 35 nM[1]. CCR7 Ligand 1 (20, 40, 60, 80, 100 μM) has dose-dependent thermo-stabilizing effect on CCR7[1]. |
| References |
| Molecular Formula | C22H29N5O5S |
|---|---|
| Molecular Weight | 475.56 |