182369-28-4
182369-28-4 structure
- Name: CB1151
- Chemical Name: CB1151
- CAS Number: 182369-28-4
- Molecular Formula: C28H46O4
- Molecular Weight: 446.66
- Catalog: Signaling Pathways Vitamin D Related VD/VDR
- Create Date: 2020-04-04 21:08:32
- Modify Date: 2024-01-12 17:28:59
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CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM[1].
| Name | CB1151 |
|---|
| Description | CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.82 nM[1] |
| In Vitro | CB1151 (0-100 nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [3H]-thymidine incorporation, exhibits an IC50 value of 0.82 nM[1]. CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC50 of 1.2 nM, the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC50=3.2nM) in MCF-7 cells transfected with the CAT reporter[1]. CB1151 shows a functional dissociation constant (Kdf) value of 3.6 nM. The ligand concentration that provides 50% of protease-resistant VDR fragment is defined by Kdf, this is different from that of the traditional dissociation constant (Kd)[2]. Cell Proliferation Assay[1] Cell Line: MCF-7 cell Concentration: 0 nM; 0.1nM; 0.5nM; 0.8nM; 1nM; 5nM; 10 nM Incubation Time: 5 days Result: Inhibits MCF-7 cells growth. |
| References |
| Molecular Formula | C28H46O4 |
|---|---|
| Molecular Weight | 446.66 |
| Storage condition | 2-8°C |