1528546-94-2
1528546-94-2 structure
- Name: BPI-9016M
- Chemical Name: BPI-9016M
- CAS Number: 1528546-94-2
- Molecular Formula: C25H18F2N4O3
- Molecular Weight: 460.43
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Met/HGFR
- Create Date: 2020-04-16 16:12:13
- Modify Date: 2024-01-15 19:39:21
-
BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma[1][2].
| Name | BPI-9016M |
|---|
| Description | BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | BPI-9016M (6.3-25 μM; 2 weeks) inhibited cell proliferation[2]. BPI-9016M (12.5-50 μM; 24 hpurs) induces accumulation of more tumor cells in the G1 phase[2]. BPI-9016M (3.1-50 μM) reduces expression of c-Met, p-c-Met, p-AKT and p-ERK in the H1299 and A549 cells in a dose-dependent manner[2]. The IC50 of BPI-9016M in several lung adenocarcinoma cell lines ( A549, H1299, H1650, H1975, HCC827, and PC-9 cells) as well as in primary lung adenocarcinoma cells are ranged from 5.3 μM to 27.1 μM[2]. Cell Proliferation Assay[2] Cell Line: A549 and H1299 cells Concentration: 6.3, 12.5, 25 μM Incubation Time: 2 weeks Result: Colony formation was significantly inhibited in a dose-dependent manner. Cell Cycle Analysis[2] Cell Line: A549 and H1299 cells Concentration: 12.5, 25, 50 μM Incubation Time: 24 hours Result: Induced accumulation of more tumor cells in the G1 phase. |
| In Vivo | BPI-9016M (60 mg/kg; p.o.; daily for 16 or 12 days) dramatically restrains tumor growth in PDX xenografts in NOD/SCID mice[2]. Animal Model: NOD/SCID mice[2] Dosage: 60 mg/kg Administration: p.o.; daily for 16 or 12 days Result: Dramatically restrained tumor growth in PDX xenografts in NOD/SCID mice. |
| References |
| Molecular Formula | C25H18F2N4O3 |
|---|---|
| Molecular Weight | 460.43 |