2183447-27-8

2183447-27-8 structure

2183447-27-8 structure

Name: Biotin-PEG8-amine
Chemical Name: Biotin-PEG8-amine
CAS Number: 2183447-27-8
Molecular Formula: C₂₈H₅₄N₄O₁₀S
Molecular Weight: 638.81
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-04-13 11:29:55
Modify Date: 2024-01-15 20:55:08
Biotin-PEG8-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Biotin-PEG8-amine
Synonyms	MFCD32263742

Description	Biotin-PEG8-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

Molecular Formula	C₂₈H₅₄N₄O₁₀S
Molecular Weight	638.81