134452-11-2

134452-11-2 structure

Name: 5-A-RU hydrochloride
Chemical Name: 5-A-RU hydrochloride
CAS Number: 134452-11-2
Molecular Formula: C₉H₁₇ClN₄O₆
Molecular Weight: 312.71
Catalog: Research Areas Inflammation/Immunology
Create Date: 2020-05-02 20:04:59
Modify Date: 2025-08-24 21:54:32
5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU hydrochloride forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules, such as glyoxal and methylglyoxal, which are derived from other metabolic pathways[1][2][3].

Name	5-A-RU hydrochloride

Description	5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU hydrochloride forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules, such as glyoxal and methylglyoxal, which are derived from other metabolic pathways[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	The MAIT antigens formed by the reactions between 5-A-RU hydrochloride and glyoxal/methylglyoxal are simple adducts, 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), respectively, which bound to MR1 as shown by crystal structures of MAIT TCR ternary complexes[1]. 5-A-RU hydrochloride presents in diverse bacteria and yeast as well as plants. 5-A-RU plays an important role in MAIT cell activation, MR1 could not be refolded efficiently with 5-ARU alone. 5-A-RU is a precursor for MAIT cell ligand[2]. 5-A-RU hydrochloride can react extemporaneously with glyoxal and methylglyoxal to generate pyrimidine adducts that activate mouse MAIT cells from STg (iVa19) and DTg (iVa19Vb6) animals[3].
In Vivo	5-A-RU hydrochloride (100 nM; i.p.; 18 hours) and methylglyoxal (MeG) are mixed extemporaneously, MAIT cells are activated in iVa19 Cα-/- Tg mice (generated on the C57BL/6 background)[3].
References	[1]. Corbett AJ, et al. T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature. 2014 May 15;509(7500):361-5. [2]. Eckle SB, et al. Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells. [3]. Soudais C, et al. In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin PrecursorDerivatives Activating Mouse MAIT Cells. J Immunol. 2015 May 15;194(10):4641-9.

Molecular Formula	C₉H₁₇ClN₄O₆
Molecular Weight	312.71

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