849022-32-8
849022-32-8 structure
- Name: BI-1230
- Chemical Name: BI-1230
- CAS Number: 849022-32-8
- Molecular Formula: C42H52N6O9S
- Molecular Weight: 816.96
- Catalog: Signaling Pathways Metabolic Enzyme/Protease HCV Protease
- Create Date: 2020-01-23 17:04:51
- Modify Date: 2024-04-06 10:25:01
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BI-1230 is potent and orally active digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity[1].
| Name | BI-1230 |
|---|
| Description | BI-1230 is potent and orally active digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 6.7 nM (HCV NS3 protease)[1] |
| In Vitro | BI-1230 (60 min incubation) exhibits an IC50 value of 6.7 nM in a Enzymatic assay[1]. BI-1230 (72 hours) shows EC50 values of 4.6 nM and <1.8 nM in a Cell-based HCVPV RNA replication Luciferase reporter assay, genotype background 1a and 1b, in Huh7 cells[1]. |
| In Vivo | BI-1230 (intravenous injection; 2mg/kg) shows good PK activity in rat: CL: 15ml/min/kg, Mean residence time after iv dose: 2.3 hours, Vss: 2.05 L/kg[1]. BI-1230 (oral administation; 5 mg/kg) shows good PK activity in rat: T1/2: 2.1 hours; Tmax: 1.8 nM; Cmax: 405 nM; AUC0-inf: 2550 nM*h; F: 42%[1]. |
| References |
| Molecular Formula | C42H52N6O9S |
|---|---|
| Molecular Weight | 816.96 |