932705-04-9
932705-04-9 structure
- Name: MK-1925
- Chemical Name: MK-1925
- CAS Number: 932705-04-9
- Molecular Formula: C19H21F3N4
- Molecular Weight: 362.4
- Create Date: 2020-01-12 14:24:50
- Modify Date: 2024-04-04 15:47:54
-
MK-1925 is a selective, orally active, brain-penetrant opioid receptor-like 1 (ORL1;NOP receptor) antagonist with binding IC50 of 8.2 nM; shows good selectivity over other opioid receptors and the hERG channel; exhibits in vivo antagonist activity against the reduction in locomotor activity induced by ORL1 agonist in mice.
| Name | MK-1925 |
|---|
| Description | MK-1925 is a selective, orally active, brain-penetrant opioid receptor-like 1 (ORL1;NOP receptor) antagonist with binding IC50 of 8.2 nM; shows good selectivity over other opioid receptors and the hERG channel; exhibits in vivo antagonist activity against the reduction in locomotor activity induced by ORL1 agonist in mice. |
|---|---|
| References | References 1. Kobayashi K, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4729-32. View Related Products by Target Opioid Receptor |
| Molecular Formula | C19H21F3N4 |
|---|---|
| Molecular Weight | 362.4 |