325990-63-4
325990-63-4 structure
- Name: Lethal toxin inhibitor DN1
- Chemical Name: Lethal toxin inhibitor DN1
- CAS Number: 325990-63-4
- Molecular Formula: C14H12FN3O
- Molecular Weight: 257.268
- Create Date: 2020-01-12 13:10:53
- Modify Date: 2022-11-22 10:01:11
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Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively; protected cells irrespectively of LT concentration and reduced the pathogenicity of an additional bacterial exotoxin and several viruses, does not prevent LT internalization and catalytic activity or caspase-1 activation, also reduced the susceptibility of Drosophila melanogaster to toxin-associated bacterial infections.
| Name | Lethal toxin inhibitor DN1 |
|---|
| Description | Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively; protected cells irrespectively of LT concentration and reduced the pathogenicity of an additional bacterial exotoxin and several viruses, does not prevent LT internalization and catalytic activity or caspase-1 activation, also reduced the susceptibility of Drosophila melanogaster to toxin-associated bacterial infections. |
|---|---|
| References | References 1. Hartmann S, et al. ACS Infect Dis. 2018 Nov 5. doi: 10.1021/acsinfecdis.8b00231. View Related Products by Target Bacterial |
| Molecular Formula | C14H12FN3O |
|---|---|
| Molecular Weight | 257.268 |