2222660-40-2
2222660-40-2 structure
- Name: DNDI-8219
- Chemical Name: DNDI-8219
- CAS Number: 2222660-40-2
- Molecular Formula: C13H10F3N3O5
- Molecular Weight: 345.234
- Catalog: Research Areas Infection
- Create Date: 2020-01-20 11:12:57
- Modify Date: 2025-08-04 10:17:42
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DNDI-8219 is a novel potent, orally active antileishmanial agent with IC50 of 0.19 uM against Leishmania donovani (L. don); also has IC050 of 0.53 and 0.15 uM against L. inf and T. cruzi, displayes promising activity in the more stringent Leishmania infantum hamster model, with better solubility and pharmacokinetic properties, as well as minimal hERG inhibition.
| Name | DNDI-8219 |
|---|
| Description | DNDI-8219 is a novel potent, orally active antileishmanial agent with IC50 of 0.19 uM against Leishmania donovani (L. don); also has IC050 of 0.53 and 0.15 uM against L. inf and T. cruzi, displayes promising activity in the more stringent Leishmania infantum hamster model, with better solubility and pharmacokinetic properties, as well as minimal hERG inhibition. |
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| References | References 1. Thompson AM, et al. J Med Chem. 2018 Mar 22;61(6):2329-2352. View Related Products by Target Parasite |
| Molecular Formula | C13H10F3N3O5 |
|---|---|
| Molecular Weight | 345.234 |