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2204280-41-9

2204280-41-9 structure
2204280-41-9 structure
  • Name: MY33-3
  • Chemical Name: MY33-3
  • CAS Number: 2204280-41-9
  • Molecular Formula: C16H13F6NS2
  • Molecular Weight: 397.397
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
  • Create Date: 2020-01-11 17:46:52
  • Modify Date: 2024-01-15 20:04:01
  • MY33-3 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation; blocks ethanol conditioned place preference, shows limited effects on ethanol-induced ataxia, and potentiates the sedative effects of ethanol in mice; increases levels of phosphorylated ALK and TrkA in neuroblastoma cells, modulates signaling pathways activated by alcohol.

Name MY33-3
Description MY33-3 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation; blocks ethanol conditioned place preference, shows limited effects on ethanol-induced ataxia, and potentiates the sedative effects of ethanol in mice; increases levels of phosphorylated ALK and TrkA in neuroblastoma cells, modulates signaling pathways activated by alcohol.
References References 1. Fernández-Calle R, et al. Neuropharmacology. 2018 May 9;137:86-95. View Related Products by Target Protein Phosphatase/PTP
Molecular Formula C16H13F6NS2
Molecular Weight 397.397
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