1952239-59-6
1952239-59-6 structure
- Name: CD12681
- Chemical Name: CD12681
- CAS Number: 1952239-59-6
- Molecular Formula: C25H33N3O4S
- Molecular Weight: 471.616
- Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
- Create Date: 2020-01-12 12:05:49
- Modify Date: 2025-09-30 22:18:47
-
CD12681 (CD-12681) is a potent, selective RORγ inverse agonist with IC50 of 19 nM, displays no activity against a panel of nuclear receptors (RORα, RARγ, LXRβ, PPARγ and VDR); inhibits IL17 production in stimulated CD4 in human hepatocytes with IC50 of 10 nM; inhibits ear swelling and IL-17 cell recruitment induced by IL-23 in mice model, CD12681 is a selective RORγ inverse agonist is sufficient to modulate an IL-23/IL-17-mediated skin inflammation.
| Name | CD12681 |
|---|
| Description | CD12681 (CD-12681) is a potent, selective RORγ inverse agonist with IC50 of 19 nM, displays no activity against a panel of nuclear receptors (RORα, RARγ, LXRβ, PPARγ and VDR); inhibits IL17 production in stimulated CD4 in human hepatocytes with IC50 of 10 nM; inhibits ear swelling and IL-17 cell recruitment induced by IL-23 in mice model, CD12681 is a selective RORγ inverse agonist is sufficient to modulate an IL-23/IL-17-mediated skin inflammation. |
|---|---|
| References | References 1. Baffert F, et al. Mol Cancer Ther. 2010 Jul;9(7):1945-55. 2. Ringel F, et al. Acta Haematol. 2014;132(1):75-86. 3. Cheon JH, et al. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182. 4. Haissaguerre M, et al. Front Pharmacol. 2018 May 15;9:527. View Related Products by Target ROR |
| Molecular Formula | C25H33N3O4S |
|---|---|
| Molecular Weight | 471.616 |