1807690-39-6
1807690-39-6 structure
- Name: Poloxin-2
- Chemical Name: Poloxin-2
- CAS Number: 1807690-39-6
- Molecular Formula: C16H15NO3
- Molecular Weight: 269.3
- Create Date: 2020-01-11 10:25:56
- Modify Date: 2024-07-17 18:58:53
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A potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM; shows >10-fold selectivity over Plk2 PBD and Plk3 PBD; significantly improved potency and selectivity over Poloxin; induces mitotic arrest and apoptosis in cultured human tumor cells at low micromolar concentrations.
| Name | Poloxin-2 |
|---|
| Description | A potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM; shows >10-fold selectivity over Plk2 PBD and Plk3 PBD; significantly improved potency and selectivity over Poloxin; induces mitotic arrest and apoptosis in cultured human tumor cells at low micromolar concentrations. |
|---|---|
| References | References 1. Scharow A, et al. ACS Chem Biol. 2015 Nov 20;10(11):2570-9. 2. Scharow A, et al. Chembiochem. 2016 Apr 15;17(8):759-67. View Related Products by Target Polo-like Kinase (PLK) |
| Molecular Formula | C16H15NO3 |
|---|---|
| Molecular Weight | 269.3 |