1541206-05-6
1541206-05-6 structure
- Name: BU09059
- Chemical Name: BU09059
- CAS Number: 1541206-05-6
- Molecular Formula: C28H37N3O5
- Molecular Weight: 495.62
- Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
- Create Date: 2020-01-20 15:48:56
- Modify Date: 2024-09-29 19:03:06
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BU09059 is a potent, selective, short-acting kappa-opioid receptor antagonist with Ki of 1.72 nM, displays 15- and 616-fold selectivity over μ- and δ-receptors respectively; BU09059 is a potent and selective κ-antagonist with pA2 of 8.62, significantly blocks U50,488-induced antinociception in vivo (3 and 10 mg/kg), demonstrates a shorter duration of κ-antagonist action in vivo.
| Name | BU09059 |
|---|
| Description | BU09059 is a potent, selective, short-acting kappa-opioid receptor antagonist with Ki of 1.72 nM, displays 15- and 616-fold selectivity over μ- and δ-receptors respectively; BU09059 is a potent and selective κ-antagonist with pA2 of 8.62, significantly blocks U50,488-induced antinociception in vivo (3 and 10 mg/kg), demonstrates a shorter duration of κ-antagonist action in vivo. |
|---|---|
| References | References 1. Casal-Dominguez JJ, et al. Send toACS Chem Neurosci. 2014 Mar 19;5(3):177-84. View Related Products by Target Opioid Receptor |
| Molecular Formula | C28H37N3O5 |
|---|---|
| Molecular Weight | 495.62 |