1449746-00-2
1449746-00-2 structure
- Name: Mefuparib hydrochloride(CVL218)
- Chemical Name: Mefuparib hydrochloride
- CAS Number: 1449746-00-2
- Molecular Formula: C17H16ClFN2O2
- Molecular Weight: 334.775
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-11 20:00:50
- Modify Date: 2024-01-02 10:54:21
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Mefuparib hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively; displays >406-fold over other major nuclear PARPs including PARP3, TNKS1, TNKS2 and PARP6; reduces poly(ADP-ribose) formation, enhances γH2AX levels, induces G2/M arrest and subsequent apoptosis in homologous recombination repair (HR)-deficient cells; shows potent in vitro and in vivo proliferation and growth inhibition against HR-deficient cancer cells and synergistic sensitization of HR-proficient xenografts to the anticancer drug temozolomide.
| Name | Mefuparib hydrochloride |
|---|
| Description | Mefuparib hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively; displays >406-fold over other major nuclear PARPs including PARP3, TNKS1, TNKS2 and PARP6; reduces poly(ADP-ribose) formation, enhances γH2AX levels, induces G2/M arrest and subsequent apoptosis in homologous recombination repair (HR)-deficient cells; shows potent in vitro and in vivo proliferation and growth inhibition against HR-deficient cancer cells and synergistic sensitization of HR-proficient xenografts to the anticancer drug temozolomide. |
|---|---|
| References | References 1. He JX, et al. Oncotarget. 2017 Jan 17;8(3):4156-4168. View Related Products by Target PARP |
| Molecular Formula | C17H16ClFN2O2 |
|---|---|
| Molecular Weight | 334.775 |