1256941-06-6
1256941-06-6 structure
- Name: BAY-386
- Chemical Name: BAY-386
- CAS Number: 1256941-06-6
- Molecular Formula: C22H25F3N4O5S
- Molecular Weight: 514.52
- Create Date: 2020-01-20 19:06:56
- Modify Date: 2025-11-30 01:23:07
-
BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM); inhibits platelet aggregation with IC50 of 0.14 uM, shows potential for oral treatment of platelet-mediated thrombosis and inflammation.
| Name | BAY-386 |
|---|
| Description | BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM); inhibits platelet aggregation with IC50 of 0.14 uM, shows potential for oral treatment of platelet-mediated thrombosis and inflammation. |
|---|---|
| References | References 1. Christoph Gerdes, et al. Discovery and in vitro pharmacology of BAY-386-a novel, reversible PAR-1 antagonist. View Related Products by Target Protease-activated Receptor (PAR) |
| Molecular Formula | C22H25F3N4O5S |
|---|---|
| Molecular Weight | 514.52 |