1197196-47-6
1197196-47-6 structure
- Name: TM2-115
- Chemical Name: TM2-115
- CAS Number: 1197196-47-6
- Molecular Formula: C29H39N5O2
- Molecular Weight: 489.664
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2020-01-20 14:30:56
- Modify Date: 2024-04-04 20:05:17
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A BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death; inhibits P. falciparum 3D7 parasites in culture with IC50 of 100 nM, >22-fold more potent than IC50 toward two human cell lines and one mouse cell line; significant reduces histone H3K4me3 levels in a concentration-dependent and exposure time-dependent manner in treatment of P. falciparum parasites.
| Name | TM2-115 |
|---|
| Description | A BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death; inhibits P. falciparum 3D7 parasites in culture with IC50 of 100 nM, >22-fold more potent than IC50 toward two human cell lines and one mouse cell line; significant reduces histone H3K4me3 levels in a concentration-dependent and exposure time-dependent manner in treatment of P. falciparum parasites. |
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| References | References 1. Malmquist NA, et al. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16708-13. 2. Malmquist NA, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):950-9. View Related Products by Target Histone Methyltransferase (HMTase) |
| Molecular Formula | C29H39N5O2 |
|---|---|
| Molecular Weight | 489.664 |