864420-54-2
864420-54-2 structure
- Name: NEDD8 inhibitor M22
- Chemical Name: NEDD8 inhibitor M22
- CAS Number: 864420-54-2
- Molecular Formula: C20H24Cl2N2
- Molecular Weight: 363.326
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-11 19:24:51
- Modify Date: 2024-09-14 17:40:56
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NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor; inhibit A549 cell proliferation completely at 30 uM (GI50=5.5 uM and GI90=19.3 uM); produces tumor inhibition in AGS xenografts in nude mice and low acute toxicity in zebrafish model; exhibts different binding mode compared with MLN4924.
| Name | NEDD8 inhibitor M22 |
|---|
| Description | NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor; inhibit A549 cell proliferation completely at 30 uM (GI50=5.5 uM and GI90=19.3 uM); produces tumor inhibition in AGS xenografts in nude mice and low acute toxicity in zebrafish model; exhibts different binding mode compared with MLN4924. |
|---|---|
| References | References 1. Lu P, et al. ACS Chem Biol. 2016 Jul 15;11(7):1901-7. View Related Products by Target Ubiquitin-activating Enzyme (E1) |
| Molecular Formula | C20H24Cl2N2 |
|---|---|
| Molecular Weight | 363.326 |