628300-71-0
628300-71-0 structure
- Name: MLN3126
- Chemical Name: MLN3126
- CAS Number: 628300-71-0
- Molecular Formula: C21H19ClN2O5S
- Molecular Weight: 446.902
- Catalog: Signaling Pathways GPCR/G Protein CCR
- Create Date: 2020-01-11 15:04:49
- Modify Date: 2024-04-02 17:04:28
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MLN3126 (MLN 3126, MLN-3126) is a potent, selective, orally available CCR9 antagonist with IC50 of 6.3 nM (CCL25-induced calcium mobilization); shows no significant antagonistic activity for other 12 chemokine receptors (CCR1, -2b, -4, -6, -7, -8, -10,CX3CR1, CXCR1, -2, -3 and -4) at 10 uM; dose dependently inhibits CCL25-induced chemotaxis of mouse thymocytes (IC90=1.8 uM); ameliorates inflammation in a T cell mediated mouse colitis model. Other Indication Phase 1 Discontinued
| Name | MLN3126 |
|---|
| Description | MLN3126 (MLN 3126, MLN-3126) is a potent, selective, orally available CCR9 antagonist with IC50 of 6.3 nM (CCL25-induced calcium mobilization); shows no significant antagonistic activity for other 12 chemokine receptors (CCR1, -2b, -4, -6, -7, -8, -10,CX3CR1, CXCR1, -2, -3 and -4) at 10 uM; dose dependently inhibits CCL25-induced chemotaxis of mouse thymocytes (IC90=1.8 uM); ameliorates inflammation in a T cell mediated mouse colitis model. Other Indication Phase 1 Discontinued |
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| References | References 1. Igaki K, et al. Int Immunopharmacol. 2018 Jul;60:160-169. 2. Narita N, et al. Drug Metab Dispos. 2018 Mar;46(3):204-213. View Related Products by Target Chemokine Receptor (CCR and CXCR) Other Indication |
| Molecular Formula | C21H19ClN2O5S |
|---|---|
| Molecular Weight | 446.902 |