2138488-38-5
2138488-38-5 structure
- Name: ZT55
- Chemical Name: ZT55
- CAS Number: 2138488-38-5
- Molecular Formula: C17H16N2O3
- Molecular Weight: 296.326
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-20 01:39:56
- Modify Date: 2024-01-07 03:15:13
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ZT55 (JAK inhibitor ZT55) is a novel potent, highly-selective tyrosine kinase JAK2 inhibitor with IC50 of 31 nM; displays no significant activity against JAK1/3 (IC50>10 uM); exhibits potent effects on the cellular JAK-STAT pathway, inhibiting tyrosine phosphorylation in JAK2V617F and downstream STAT3/5 transcription factors; inhibits the proliferation of the JAK2V617F-expressing HEL cell line, leading to cell cycle arrest at the G2/M phase and induction of caspase-dependent apoptosis; significantly suppressed the growth of HEL xenograft tumors in vivo, blocks erythroid colony formation of peripheral blood hematopoietic progenitors from patients carrying the JAK2V617F mutation.
| Name | ZT55 |
|---|
| Description | ZT55 (JAK inhibitor ZT55) is a novel potent, highly-selective tyrosine kinase JAK2 inhibitor with IC50 of 31 nM; displays no significant activity against JAK1/3 (IC50>10 uM); exhibits potent effects on the cellular JAK-STAT pathway, inhibiting tyrosine phosphorylation in JAK2V617F and downstream STAT3/5 transcription factors; inhibits the proliferation of the JAK2V617F-expressing HEL cell line, leading to cell cycle arrest at the G2/M phase and induction of caspase-dependent apoptosis; significantly suppressed the growth of HEL xenograft tumors in vivo, blocks erythroid colony formation of peripheral blood hematopoietic progenitors from patients carrying the JAK2V617F mutation. |
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| References | References 1. Hu M, et al. J Exp Clin Cancer Res. 2019 Feb 4;38(1):49. View Related Products by Target JAK |
| Molecular Formula | C17H16N2O3 |
|---|---|
| Molecular Weight | 296.326 |