2130033-55-3
2130033-55-3 structure
- Name: PHY34
- Chemical Name: PHY34
- CAS Number: 2130033-55-3
- Molecular Formula: C30H30O12
- Molecular Weight: 582.6
- Catalog: Signaling Pathways Autophagy Autophagy
- Create Date: 2020-01-12 10:07:50
- Modify Date: 2024-04-09 11:11:05
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PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM); disrupts lysosomal function, significantly inhibits the growth of cancer cell lines in hollow fibers, as well as reduces ovarian tumor burden in a xenograft model.
| Name | PHY34 |
|---|
| Description | PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM); disrupts lysosomal function, significantly inhibits the growth of cancer cell lines in hollow fibers, as well as reduces ovarian tumor burden in a xenograft model. |
|---|---|
| References | References 1. Young AN, et al. Mol Cancer Ther. 2018 Jul 17. pii: molcanther.1195.2017. View Related Products by Target Autophagy |
| Molecular Formula | C30H30O12 |
|---|---|
| Molecular Weight | 582.6 |
| Storage condition | -20°C |