1380887-60-4
1380887-60-4 structure
- Name: MK-8825
- Chemical Name: MK-8825
- CAS Number: 1380887-60-4
- Molecular Formula: C31H30F2N6O3
- Molecular Weight: 572.617
- Create Date: 2020-01-11 19:39:50
- Modify Date: 2024-04-05 11:04:31
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MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP; blocks hCGRP-stimulated cAMP responses in HEK293 cells stably expressing the human CGRP receptor with IC50 of 0.23 nM; possesses significantly improved in vivo potency in rat pharmacodynamic models. Migraine Phase 1 Clinical
| Name | MK-8825 |
|---|
| Description | MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP; blocks hCGRP-stimulated cAMP responses in HEK293 cells stably expressing the human CGRP receptor with IC50 of 0.23 nM; possesses significantly improved in vivo potency in rat pharmacodynamic models. Migraine Phase 1 Clinical |
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| References | References 1. Bell IM, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3941-5. 2. Michot B, et al. Eur J Pain. 2015 Feb;19(2):281-90. 3. Romero-Reyes M, et al. Exp Neurol. 2015 Sep;271:95-103. 4. Feistel S, et al. J Headache Pain. 2013 Nov 20;14:93. View Related Products by Target CGRP Receptor Migraine |
| Molecular Formula | C31H30F2N6O3 |
|---|---|
| Molecular Weight | 572.617 |