393834-37-2
393834-37-2 structure
- Name: ATV399
- Chemical Name: N-(4-{[2-(3-Pyridinyl)-1-piperidinyl]sulfonyl}phenyl)-1,3-benzodioxole-5-carboxamide
- CAS Number: 393834-37-2
- Molecular Formula: C24H23N3O5S
- Molecular Weight: 465.522
- Create Date: 2020-01-11 09:34:09
- Modify Date: 2024-04-11 18:45:34
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ATV399 (ATV-399) is a novel small molecule that dose-dependently reduces the cleaved caspase9 levels with IC50 of 3.3 uM, inhibits dimerization of iNOS; inhibits cleaved caspase-9 activation and subsequent β-cell apoptosis induced by a combination of IL-1β, IFN-γ and high glucose.
| Name | N-(4-{[2-(3-Pyridinyl)-1-piperidinyl]sulfonyl}phenyl)-1,3-benzodioxole-5-carboxamide |
|---|---|
| Synonyms |
1,3-Benzodioxole-5-carboxamide, N-[4-[[2-(3-pyridinyl)-1-piperidinyl]sulfonyl]phenyl]-
N-(4-{[2-(3-Pyridinyl)-1-piperidinyl]sulfonyl}phenyl)-1,3-benzodioxole-5-carboxamide |
| Description | ATV399 (ATV-399) is a novel small molecule that dose-dependently reduces the cleaved caspase9 levels with IC50 of 3.3 uM, inhibits dimerization of iNOS; inhibits cleaved caspase-9 activation and subsequent β-cell apoptosis induced by a combination of IL-1β, IFN-γ and high glucose. |
|---|---|
| References | References 1. Zhong L, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14388. View Related Products by Target Nitric Oxide Synthase (NOS) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H23N3O5S |
| Molecular Weight | 465.522 |
| Exact Mass | 465.135834 |
| LogP | 3.00 |
| Index of Refraction | 1.657 |