2089320-99-8
2089320-99-8 structure
- Name: VT-1598
- Chemical Name: Vt-1598
- CAS Number: 2089320-99-8
- Molecular Formula: C31H20F4N6O2
- Molecular Weight: 584.523
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2020-01-20 00:36:56
- Modify Date: 2022-07-20 17:49:46
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VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM; is more selective for fungal CYP51 than related human CYP enzymes such as CYP3A4; exhibits excellent potency against yeast, dermatophyte, and mold fungal pathogens.
| Name | Vt-1598 |
|---|---|
| Synonyms |
Benzonitrile, 4-[[4-[2-[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl]-3-pyridinyl]ethynyl]phenoxy]methyl]-
Vt-1598 4-{[4-({6-[2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl]-3-pyridinyl}ethynyl)phenoxy]methyl}benzonitrile |
| Description | VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM; is more selective for fungal CYP51 than related human CYP enzymes such as CYP3A4; exhibits excellent potency against yeast, dermatophyte, and mold fungal pathogens. |
|---|---|
| References | References 1. Hargrove TY, et al. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00570-17. 2. Yates CM, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3243-3248. 3. Wiederhold NP, et al. J Antimicrob Chemother. 2018 Feb 1;73(2):404-408. View Related Products by Target Fungal |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 770.9±70.0 °C at 760 mmHg |
| Molecular Formula | C31H20F4N6O2 |
| Molecular Weight | 584.523 |
| Flash Point | 420.0±35.7 °C |
| Exact Mass | 584.158386 |
| LogP | 6.56 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.614 |