172907-03-8
172907-03-8 structure
- Name: PB 28 dihydrochloride
- Chemical Name: PB28 dihydrochloride
- CAS Number: 172907-03-8
- Molecular Formula: C24H40Cl2N2O
- Molecular Weight: 443.493
- Catalog: Signaling Pathways Anti-infection SARS-CoV
- Create Date: 2020-01-11 18:41:37
- Modify Date: 2024-01-16 18:04:27
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A potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively; inhibits cancer cell growth, modulates P-glycoprotein, and synergizes with doxorubicin in MCF7 and MCF ADR cells with IC50 in nanomolar range; increase G0-G1-phase fraction and caspase-independent apoptosis, also reduces P-gp expression.
| Name | PB28 dihydrochloride |
|---|---|
| Synonyms |
1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-1-naphthalenyl)propyl]piperazine dihydrochloride
PB28 dihydrochloride 1-Cyclohexyl-4-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl)piperazine dihydrochloride MFCD06798349 Piperazine, 1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]-, hydrochloride (1:2) |
| Description | A potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively; inhibits cancer cell growth, modulates P-glycoprotein, and synergizes with doxorubicin in MCF7 and MCF ADR cells with IC50 in nanomolar range; increase G0-G1-phase fraction and caspase-independent apoptosis, also reduces P-gp expression. |
|---|---|
| References | References 1. Azzariti A, et al. Mol Cancer Ther. 2006 Jul;5(7):1807-16. 2. Cassano G, et al. Cell Calcium. 2006 Jul;40(1):23-8. 3. Berardi F, et al. J Med Chem. 1996 Jan 5;39(1):176-82. View Related Products by Target Sigma Receptor |
| Molecular Formula | C24H40Cl2N2O |
|---|---|
| Molecular Weight | 443.493 |
| Exact Mass | 442.251770 |