1488362-55-5
1488362-55-5 structure
- Name: ML375
- Chemical Name: ml375
- CAS Number: 1488362-55-5
- Molecular Formula: C23H15ClF2N2O2
- Molecular Weight: 424.827
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2020-01-20 19:18:56
- Modify Date: 2024-10-11 19:14:21
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ML375 (VU-0483253) is a potent, highly selective M5 NAM with submicromolar potency (human M5 IC50=300 nM, rat M5 IC50=790 nM, M1-M4 IC50> 30 uM), exhibts excellent multispecies PK, high CNS penetration, and enantiospecific inhibition.
| Name | ml375 |
|---|---|
| Synonyms |
ml375
(9bS)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one 5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-, (9bS)- |
| Description | ML375 (VU-0483253) is a potent, highly selective M5 NAM with submicromolar potency (human M5 IC50=300 nM, rat M5 IC50=790 nM, M1-M4 IC50> 30 uM), exhibts excellent multispecies PK, high CNS penetration, and enantiospecific inhibition. |
|---|---|
| References | References 1. Gentry PR, et al. J Med Chem. 2013 Nov 27;56(22):9351-5. 2. Berizzi AE, et al. Mol Pharmacol. 2016 Oct;90(4):427-36. View Related Products by Target mAChR |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 611.6±55.0 °C at 760 mmHg |
| Molecular Formula | C23H15ClF2N2O2 |
| Molecular Weight | 424.827 |
| Flash Point | 323.7±31.5 °C |
| Exact Mass | 424.079010 |
| LogP | 2.65 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.699 |