709676-56-2

709676-56-2 structure

Name: TTK21
Chemical Name: N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
CAS Number: 709676-56-2
Molecular Formula: C₁₇H₁₅ClF₃NO₂
Molecular Weight: 357.755
Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
Create Date: 2020-01-11 17:46:32
Modify Date: 2024-01-06 18:03:38
TTK21 (CBP-p300 activator TTK21) is a small molecule activator of CBP/p300 histone acetyltransferase activity with a maximal effect at a concentration of 275 uM; induces acetylation of histones H3 and H4 in vitro but not H2B and H2A; promotes neurogenesis and extends memory duration in adult mice, promotes regeneration and sprouting of sensory and motor axons, as well as recovery of sensory and motor functions in both the mouse and rat model of spinal cord injury.

Name	N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
Synonyms	Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy- N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide

Description	TTK21 (CBP-p300 activator TTK21) is a small molecule activator of CBP/p300 histone acetyltransferase activity with a maximal effect at a concentration of 275 uM; induces acetylation of histones H3 and H4 in vitro but not H2B and H2A; promotes neurogenesis and extends memory duration in adult mice, promotes regeneration and sprouting of sensory and motor axons, as well as recovery of sensory and motor functions in both the mouse and rat model of spinal cord injury.
References	References 1. Chatterjee S, et al. J Neurosci. 2013 Jun 26;33(26):10698-712. 2. Hutson TH, et al. Sci Transl Med. 2019 Apr 10;11(487). pii: eaaw2064. View Related Products by Target Histone Acetyltransferase (HAT)