642473-62-9

642473-62-9 structure

Name: 3M-011
Chemical Name: N-{1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methyl-2-propanyl}methanesulfonamide
CAS Number: 642473-62-9
Molecular Formula: C₁₈H₂₅N₅O₃S
Molecular Weight: 391.488
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2020-01-12 12:13:49
Modify Date: 2023-01-16 19:50:27
A potent TLR7/8 agonist and cytokine inducer; stimulates type I interferon (IFN) and other cytokines such as TNF-alpha, IL-12, and IFN-gamma from rat peripheral blood mononuclear cells; induces IL-12 and COX-2 expression in mDC from HIV+ and HIV- individuals, and inhibits H3N2 influenza viral replication in the nasal cavity; potentiates NK cytotoxicity, and shows antitumor effects in scid/B6 mice and scid/NOD mice.

Name	N-{1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methyl-2-propanyl}methanesulfonamide
Synonyms	Methanesulfonamide, N-[2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl]- N-{1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methyl-2-propanyl}methanesulfonamide

Description	A potent TLR7/8 agonist and cytokine inducer; stimulates type I interferon (IFN) and other cytokines such as TNF-alpha, IL-12, and IFN-gamma from rat peripheral blood mononuclear cells; induces IL-12 and COX-2 expression in mDC from HIV+ and HIV- individuals, and inhibits H3N2 influenza viral replication in the nasal cavity; potentiates NK cytotoxicity, and shows antitumor effects in scid/B6 mice and scid/NOD mice.
References	References 1. Martinson JA, et al. Cell Immunol. 2007 Nov-Dec;250(1-2):75-84. 2. Hammerbeck DM, et al. Antiviral Res. 2007 Jan;73(1):1-11. View Related Products by Target Toll-like Receptor (TLR)