524962-01-4
524962-01-4 structure
- Name: BeKm-1
- Chemical Name: BeKm 1
- CAS Number: 524962-01-4
- Molecular Formula: C174H261N51O52S6
- Molecular Weight:
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2020-01-20 18:01:56
- Modify Date: 2024-04-05 18:00:22
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A potent, selective peptide inhibitor of hERG channel with IC50 of 3.3 nM for hERG1 channels; displays no effect at 100 nM on hEAG, hSK1, rSK2, hIK, hBK, KCNQ1/KCNE1, KCNQ2/KCNQ3, KCNQ4 channels, and minimal effect on rELK1; prolongs QTc intervals significantly and concentration-dependently (4.7 and 16.3% at 10 and 100 nM, respectively).
| Name | BeKm 1 |
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| Description | A potent, selective peptide inhibitor of hERG channel with IC50 of 3.3 nM for hERG1 channels; displays no effect at 100 nM on hEAG, hSK1, rSK2, hIK, hBK, KCNQ1/KCNE1, KCNQ2/KCNQ3, KCNQ4 channels, and minimal effect on rELK1; prolongs QTc intervals significantly and concentration-dependently (4.7 and 16.3% at 10 and 100 nM, respectively). |
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| References | References 1. Korolkova YV, et al. J Biol Chem. 2002 Nov 8;277(45):43104-9. 2. Korolkova YV, et al. J Biol Chem. 2001 Mar 30;276(13):9868-76. 3. Qu Y, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):2-8. 4. Qu Y, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):2-8. View Related Products by Target Potassium Channel |
| Molecular Formula | C174H261N51O52S6 |
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