496793-75-0
496793-75-0 structure
- Name: AZSMO-23
- Chemical Name: N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]nicotinamide
- CAS Number: 496793-75-0
- Molecular Formula: C19H13ClN4O
- Molecular Weight: 348.786
- Create Date: 2020-01-12 10:20:31
- Modify Date: 2024-09-16 15:31:19
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AZSMO-23 (AZSMO 23, AZSMO23) is a potent hERG potassium channel (Kv11.1) activator that activates WT hERG pre-pulse and tail current with EC50 of 28.6 and 11.2 μM respectively; increases pre-pulse current at +40 mV by 952% and tail current at −30 mV by 238% at 100 uM; blocks the mutant channel hERG Y652A, but shows enhanced activator activity against another mutant channel hERG F656T, also blocks hKv4.3-hKChIP2.2, hCav3.2 and hKv1.5 and activated hCav1.2/β2/α2δ channels.
| Name | N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]nicotinamide |
|---|---|
| Synonyms |
3-Pyridinecarboxamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]nicotinamide |
| Description | AZSMO-23 (AZSMO 23, AZSMO23) is a potent hERG potassium channel (Kv11.1) activator that activates WT hERG pre-pulse and tail current with EC50 of 28.6 and 11.2 μM respectively; increases pre-pulse current at +40 mV by 952% and tail current at −30 mV by 238% at 100 uM; blocks the mutant channel hERG Y652A, but shows enhanced activator activity against another mutant channel hERG F656T, also blocks hKv4.3-hKChIP2.2, hCav3.2 and hKv1.5 and activated hCav1.2/β2/α2δ channels. |
|---|---|
| References | References 1. Mannikko R, et al. Br J Pharmacol. 2015 Jun;172(12):3112-25. View Related Products by Target Potassium Channel |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C19H13ClN4O |
| Molecular Weight | 348.786 |
| Exact Mass | 348.077789 |
| LogP | 3.48 |
| Index of Refraction | 1.742 |