1467047-25-1

1467047-25-1 structure

Name: SRS11-92
Chemical Name: Ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate
CAS Number: 1467047-25-1
Molecular Formula: C₂₂H₂₈N₂O₂
Molecular Weight: 352.470
Create Date: 2020-01-11 19:52:50
Modify Date: 2024-01-12 11:39:31
SRS11-92 (SRS 11-92) is a small molecule inhibitor of Ferroptosis and a derivative of Ferrostatin-1 (Fer-1), inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM; inhibits iron-induced cell death in isolated mouse kidney proximal tubules at 2 uM, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM; also increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington’s disease in a concentration-dependent manner.

Name	Ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate
Synonyms	Benzoic acid, 4-(cyclohexylamino)-3-[(phenylmethyl)amino]-, ethyl ester Ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate

Description	SRS11-92 (SRS 11-92) is a small molecule inhibitor of Ferroptosis and a derivative of Ferrostatin-1 (Fer-1), inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM; inhibits iron-induced cell death in isolated mouse kidney proximal tubules at 2 uM, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM; also increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington’s disease in a concentration-dependent manner.
References	References 1. Cotticelli MG, et al. J Pharmacol Exp Ther. 2019 Jan 11. pii: jpet.118.252759. 2. Linkermann A, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41. View Related Products by Target Ferroptosis