1377997-28-8
1377997-28-8 structure
- Name: EZH2-IN-3
- Chemical Name: 3-Chloro-4-[2-cyano-3-(4-pyridazinyl)phenoxy]-N-(2,2,6,6-tetramethyl-4-piperidinyl)benzamide
- CAS Number: 1377997-28-8
- Molecular Formula: C27H28ClN5O2
- Molecular Weight: 489.996
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2020-01-11 20:49:49
- Modify Date: 2025-08-27 19:30:14
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EZH2-IN-3 is a highly selective small molecule inhibitor of EZH2 and EZH1 with IC50 of 21/197/213 nM for wt EZH2/EZH2 Y641N/wt EZH1 respectively; suppresses global histone H3-lysine 27 methylation and cause selective proliferation defects.
| Name | 3-Chloro-4-[2-cyano-3-(4-pyridazinyl)phenoxy]-N-(2,2,6,6-tetramethyl-4-piperidinyl)benzamide |
|---|---|
| Synonyms |
3-Chloro-4-[2-cyano-3-(4-pyridazinyl)phenoxy]-N-(2,2,6,6-tetramethyl-4-piperidinyl)benzamide
Benzamide, 3-chloro-4-[2-cyano-3-(4-pyridazinyl)phenoxy]-N-(2,2,6,6-tetramethyl-4-piperidinyl)- |
| Description | EZH2-IN-3 is a highly selective small molecule inhibitor of EZH2 and EZH1 with IC50 of 21/197/213 nM for wt EZH2/EZH2 Y641N/wt EZH1 respectively; suppresses global histone H3-lysine 27 methylation and cause selective proliferation defects. |
|---|---|
| References | References 1. Garapaty-Rao S, et al. Chem Biol. 2013 Nov 21;20(11):1329-39. View Related Products by Target Histone Methyltransferase (HMTase) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 666.4±55.0 °C at 760 mmHg |
| Molecular Formula | C27H28ClN5O2 |
| Molecular Weight | 489.996 |
| Flash Point | 356.8±31.5 °C |
| Exact Mass | 489.193146 |
| LogP | 4.63 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.631 |