1179347-23-9

1179347-23-9 structure

Name: MT47-100
Chemical Name: 2,4-Dihydroxy-6-(2'-hydroxy-4-biphenylyl)-3-quinolinecarbonitrile
CAS Number: 1179347-23-9
Molecular Formula: C₂₂H₁₄N₂O₃
Molecular Weight: 354.358
Create Date: 2020-01-12 11:43:16
Modify Date: 2024-07-19 13:24:02
A novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the β1 or β2 isoform, respectively; maximally activates α1β1γ1 approximately 2.5-fold with half-maximal activation Ka of 3.7 uM and activates all AMPKβ1 complexes regardless α or γ isoforms; directly inhibits AMPKβ2 complexes independently of α or γ isoforms with Ki of 24.8 uM, this inhibition is dependent on the β2 carbohydrate-binding module (CBM) and independent of β2-Ser108 phosphorylation; augmentes glucose-stimulated insulin secretion from isolated mouse pancreatic islets via a β2-dependent mechanism.

Name	2,4-Dihydroxy-6-(2'-hydroxy-4-biphenylyl)-3-quinolinecarbonitrile
Synonyms	3-Quinolinecarbonitrile, 2,4-dihydroxy-6-(2'-hydroxy[1,1'-biphenyl]-4-yl)- MFCD30802280 2,4-Dihydroxy-6-(2'-hydroxy-4-biphenylyl)-3-quinolinecarbonitrile

Description	A novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the β1 or β2 isoform, respectively; maximally activates α1β1γ1 approximately 2.5-fold with half-maximal activation Ka of 3.7 uM and activates all AMPKβ1 complexes regardless α or γ isoforms; directly inhibits AMPKβ2 complexes independently of α or γ isoforms with Ki of 24.8 uM, this inhibition is dependent on the β2 carbohydrate-binding module (CBM) and independent of β2-Ser108 phosphorylation; augmentes glucose-stimulated insulin secretion from isolated mouse pancreatic islets via a β2-dependent mechanism.
References	References 1. Scott JW, et al. Chem Biol. 2015 Jun 18;22(6):705-11. View Related Products by Target AMPK