1061604-41-8

1061604-41-8 structure

Name: 3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Chemical Name: 3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
CAS Number: 1061604-41-8
Molecular Formula: C₁₃H₁₂N₂O₄
Molecular Weight: 260.245
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2019-12-19 16:02:48
Modify Date: 2024-01-06 09:21:47
Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.

Name	3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Synonyms	MFCD29054753 3-(4-Hydroxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2,6-piperidinedione 2,6-Piperidinedione, 3-(1,3-dihydro-4-hydroxy-1-oxo-2H-isoindol-2-yl)-

Description	Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.