685121-45-3
685121-45-3 structure
- Name: SynuClean-D
- Chemical Name: SynuClean-D
- CAS Number: 685121-45-3
- Molecular Formula: C13H5F3N4O5
- Molecular Weight: 354.20
- Catalog: Signaling Pathways Others Others
- Create Date: 2019-12-08 14:50:18
- Modify Date: 2025-08-25 23:37:28
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SynuClean-D (SC-D) is an inhibitor of α-synuclein aggregation, disrupts mature amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease[1].
| Name | SynuClean-D |
|---|
| Description | SynuClean-D (SC-D) is an inhibitor of α-synuclein aggregation, disrupts mature amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease[1]. |
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| Related Catalog | |
| In Vitro | SynuClean-D significantly reduces the in vitro aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. Computational analysis suggests that SynuClean-D can bind to cavities in mature α-synuclein fibrils and, indeed, it displays a strong fibril disaggregation activity[1]. |
| In Vivo | The treatment with SynuClean-D of two parkinson’s disease (PD) Caenorhabditis elegans models, expressing α-synuclein either in muscle or in dopaminergic neurons, significantly reduces the toxicity exerted by α-synuclein. SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. More importantly, this compound is able to rescue dopaminergic neurons from α-synuclein-induced degeneration[1]. |
| References |
| Molecular Formula | C13H5F3N4O5 |
|---|---|
| Molecular Weight | 354.20 |