1370363-74-8
1370363-74-8 structure
- Name: CO23
- Chemical Name: CO23
- CAS Number: 1370363-74-8
- Molecular Formula: C19H18I2N2O4
- Molecular Weight: 592.17
- Catalog: Research Areas Endocrinology
- Create Date: 2019-12-08 13:10:19
- Modify Date: 2025-10-14 16:10:33
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CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier[1].
| Name | CO23 |
|---|
| Description | CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier[1]. |
|---|---|
| Related Catalog | |
| Target |
TRα[1] |
| In Vivo | CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively[1]. Animal Model: Hypothyroid Wistar rats[1] Dosage: 0.04, 0.8, 2.5, and 5.0 nmol/g Administration: Ip Result: Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective. |
| References |
| Molecular Formula | C19H18I2N2O4 |
|---|---|
| Molecular Weight | 592.17 |