2246380-70-9

2246380-70-9 structure

Name: MAC glucuronide α-hydroxy lactone-linked SN-38
Chemical Name: Stabilized lactone
CAS Number: 2246380-70-9
Molecular Formula: C₅₀H₅₄N₆O₂₀S
Molecular Weight: 1091.06
Catalog: Signaling Pathways Antibody-drug Conjugate Drug-Linker Conjugates for ADC
Create Date: 2019-10-08 11:13:52
Modify Date: 2025-08-26 13:34:15
Stabilized lactone (Drug linker 2) is a stabilized lactone-linked SN-38 drug linker. Stabilized lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively[1].

Name	Stabilized lactone

Description	Stabilized lactone (Drug linker 2) is a stabilized lactone-linked SN-38 drug linker. Stabilized lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC
References	[1]. Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072.

Molecular Formula	C₅₀H₅₄N₆O₂₀S
Molecular Weight	1091.06