2246380-69-6

2246380-69-6 structure

Name: MAC glucuronide phenol-linked SN-38
Chemical Name: pH-susceptible lactone
CAS Number: 2246380-69-6
Molecular Formula: C₅₀H₅₄N₆O₂₀S
Molecular Weight: 1091.06
Catalog: Signaling Pathways Antibody-drug Conjugate Drug-Linker Conjugates for ADC
Create Date: 2019-10-08 10:24:52
Modify Date: 2025-08-27 07:35:00
pH-susceptible lactone (Drug linker 1) is a pH-susceptible lactone-linked SN-38 drug linker. pH-susceptible lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively[1].

Name	pH-susceptible lactone

Description	pH-susceptible lactone (Drug linker 1) is a pH-susceptible lactone-linked SN-38 drug linker. pH-susceptible lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC
References	[1]. Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072.

Molecular Formula	C₅₀H₅₄N₆O₂₀S
Molecular Weight	1091.06