2189366-77-4

2189366-77-4 structure

Name: Compound 919278
Chemical Name: LTβR-IN-1
CAS Number: 2189366-77-4
Molecular Formula: C₁₈H₁₆N₄O₂
Molecular Weight: 320.35
Catalog: Research Areas Metabolic Disease
Create Date: 2019-10-08 20:42:29
Modify Date: 2025-08-25 12:16:15
LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor with an IC50 of 10 μM. LTβR-IN-1 is potent in TWEAK-stimulated p52 translocation assays with an IC50 of 10 μM and did not alter TNF-α–induced p65 nuclear translocation[1].

Name	LTβR-IN-1

Description	LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor with an IC50 of 10 μM. LTβR-IN-1 is potent in TWEAK-stimulated p52 translocation assays with an IC50 of 10 μM and did not alter TNF-α–induced p65 nuclear translocation[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	IC50: 10 μM (LTβR，p52 translocation)[1]
References	[1]. Henry KL, et al. CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Sci Signal. 2018 Jul 31;11(541).

Molecular Formula	C₁₈H₁₆N₄O₂
Molecular Weight	320.35