2071195-74-7

2071195-74-7 structure

Name: Epertinib hydrochloride
Chemical Name: Epertinib hydrochloride
CAS Number: 2071195-74-7
Molecular Formula: C₃₀H₂₈Cl₂FN₅O₃
Molecular Weight: 596.48
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2019-10-08 15:30:52
Modify Date: 2025-09-16 16:08:02
Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib shows potent antitumor activity[1].

Name	Epertinib hydrochloride

Description	Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib shows potent antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:1.48 nM (IC50) HER4:2.49 nM (IC50) HER2:7.15 nM (IC50)
References	[1]. [1]. Tanaka H, et al. Preclinical antitumor activity of S-222611, an oral reversible tyrosine kinase inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2. Cancer Sci. 2014 Aug;105(8):1040-8.

Molecular Formula	C₃₀H₂₈Cl₂FN₅O₃
Molecular Weight	596.48