1279680-68-0

1279680-68-0 structure

Name: CL2A-SN-38
Chemical Name: CL2A-SN-38
CAS Number: 1279680-68-0
Molecular Formula: C₇₃H₉₇N₁₁O₂₂
Molecular Weight: 1480.61
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2019-10-13 22:14:35
Modify Date: 2025-08-27 13:35:34
CL2A-SN-38, SN-38 (topoisomerase-I inhibitor) derivative, is a peptide linker. CL2A-SN-38 is conjugated to the anti-Trop-2-humanized antibody, SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, provides significant and specific antitumor effects against a range of human solid tumor types[1].

Name	CL2A-SN-38

Description	CL2A-SN-38, SN-38 (topoisomerase-I inhibitor) derivative, is a peptide linker. CL2A-SN-38 is conjugated to the anti-Trop-2-humanized antibody, SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, provides significant and specific antitumor effects against a range of human solid tumor types[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Research Areas >> Inflammation/Immunology
Target	Alkyl/ether
References	[1]. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.

Molecular Formula	C₇₃H₉₇N₁₁O₂₂
Molecular Weight	1480.61