1361217-07-3

1361217-07-3 structure

Name: AMG-1694
Chemical Name: AMG-1694
CAS Number: 1361217-07-3
Molecular Formula: C₂₃H₃₀F₃N₃O₄S₂
Molecular Weight: 533.63
Catalog: Signaling Pathways Metabolic Enzyme/Protease Glucokinase
Create Date: 2019-10-09 13:28:29
Modify Date: 2024-01-10 17:42:28
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1].

Name	AMG-1694

Description	AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Glucokinase Research Areas >> Metabolic Disease
Target	IC50: 7 nM (GK-GKRP)[1]
In Vitro	AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50 of 0.020 μM in the presence of GKRP[1].
References	[1]. Lloyd DJ, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504(7480):437-40.

Molecular Formula	C₂₃H₃₀F₃N₃O₄S₂
Molecular Weight	533.63