1672662-07-5

1672662-07-5 structure

1672662-07-5 structure

Name: (Rac)-PT2399
Chemical Name: Rac-PT2399
CAS Number: 1672662-07-5
Molecular Formula: C₁₇H₁₀F₅NO₄S
Molecular Weight: 419.32
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
Create Date: 2019-09-07 19:16:16
Modify Date: 2024-04-04 22:24:53
Rac-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM[1].

Name	Rac-PT2399

Description	Rac-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 0.01 μM (HIF-2α)[1]
References	[1]. Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385). J Med Chem. 2018 Nov 8;61(21):9691-9721.

Molecular Formula	C₁₇H₁₀F₅NO₄S
Molecular Weight	419.32